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Mitochondrial Function Controls Proliferation and Early Differentiation Potential of Embryonic Stem Cells
摘要：多功能性干细胞给再生医学带来了广阔的前景是由于其强大的自我复制能力，以及可以分化成人体不同组织的细胞的潜能。在最近的研究中，我们证实了正确的线粒体功能对未分化胚胎干细胞的增殖是必要的。在自我复制的条件下衰减线粒体功能使得这些细胞更加依赖糖酵解，并且与 Nanog，Oct4，以及 Sox2 的基因储备的增长联系起来。与此相反，在分化的最初七天，衰减线粒体功能导致 Oct4，Nanog 以及 Sox2 正常复压。然而当发现多元 Hox 基因异常转录，细胞分化潜能作出妥协。此外，在线粒体功能分化条件下，成瘤细胞继续保持着。因此，我们的研究结果是在胚胎干细胞增殖的过程中确立正常线粒体功能，调节分化以及防止在分化过程中成瘤细胞的出现。
附上原文摘要：
Pluripotent stem cells hold significant promise in regenerative medicine due to their unlimited capacity for self-renewal, and potential to differentiate into any cell type of the body. In the current study, we demonstrate that proper mitochondrial function is essential for proliferation of undifferentiated embryonic stem cells (ESCs). Attenuating mitochondrial function under self-renewing conditions makes these cells more glycolytic-dependent, and is associated with an increase in the mRNA reserves of Nanog, Oct4 and Sox2. In contrast, attenuating mitochondrial function during the first 7 days of differentiation results in normal repression of Oct4, Nanog and Sox2. However differentiation potential is compromised as revealed by abnormal transcription of multiple Hox genes. Furthermore, under differentiating conditions in which mitochondrial function is attenuated, tumorigenic cells continue to persist. Our results, therefore establish the importance of normal mitochondrial function in ESC proliferation, regulating differentiation, and preventing the emergence of tumorigenic cells during the process of differentiation.
链接地址：http://onlinelibrary.wiley.com/doi/10.1002/stem.590/abstract;jsessionid=E1C24B895F7ABE1930CE508C97A45FC4.d03t02
相关链接：http://www.chinastemcell.org/page/yanjiu_jszc.aspx?InfoTypeID=11
