戴建武

戴建武，研究员，博士生导师

        武汉大学生物系细胞生物学专业学士；北京大学生物物理学专业硕士；美国 Duke University 细胞生物学专业博士；哈佛大学医学院博士后。在包括 CELL 在内的国际学术期刊上发表论文近80篇。2003 年回国在中国科学院遗传与发育生物学研究所任研究员，博士生导师，是中国科学院 “ 百人计划 ” 入选者；国家杰出青年基金（生物材料领域）获得者；国家重大科学研究计划（973管理）“ 调控干细胞自我更新能力的分子网络研究 ” 项目首席科学家。回国后已经培养优秀博士毕业生11名，获2010年度益海嘉里优秀导师奖。研究领域是再生医学。

主要研究方向有：
        1．干细胞自我更新和定向分化  
        2．功能生物材料引导组织再生与创伤修复。

课题研究组成员：
       肖志峰 博士 副研究员；陈   冰 博士 副研究员；赵燕南 博士 助理研究员

博士研究生
       高原；韩津；韩倩倩；曹佳妮；施春英；苏冠男；高健；陈磊；韩素芳；魏建树

1.Han, Q., Jin, W., Xiao, Z., Ni, H., Wang, J., Kong, J., Wu, J., Liang, W., Chen, L., Zhao, Y., Chen, B., and Dai, J.* (2010) The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein. Biomaterials. in press

2.Zhang, J., Wang, X., Chen, B., Xiao, Z., Li, W., Lu, Y. and Dai, J.* (2010) The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development. Oncology Letters. in press.

3.Liang, W.,Han, Q.,Jin, W., Xiao, Z., Huang, J., Ni, H., Chen, B., Kong, J., Wu,J.and Dai, J.* (2010). The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF. Biomaterials. Epub ahead of print

4.Yan, X., Chen, B., Lin, Y., Li, Y., Xiao, Z., Hou, X., Tan, Q.* and Dai, J.* (2010) Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. Diabetes Research and Clinical Practice. Epub ahead of print

5.Fan, J., Xiao, Z., Zhang, H., Chen, B., Tang, G., Hou, X., Ding, W., Wang, B., Zhang, P., Dai, J.* and Xu, R.* (2010) Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promotes axonal regeneration and partial functional recovery after complete spinal cord transaction. J Neurotrauma. Epub ahead of print.

6.Gao, Y., Wang, X., Han, J., Xiao, Z., Chen, B., Su, G., Dai, J.* (2010) The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics. 37(7):461-5

7.Chen, W., Shi, C., Yi, S., Chen, B., Zhang, W., Fang, Z., Wei, Z., Jiang, S., Sun, X., Hou, X., Xiao, Z., Ye, G. and Dai, J.* (2010) Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. J Urol. 183(6):2432-9.

8.Wang, X. and Dai, J.* (2010) Isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells. 28(5):885-93 (invited review).

9.Zhang, W., Wang, X., Xiao, Z., Liu, W., Chen, B. and Dai, J.* (2010) Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA. Biochem Biophys Res Commun. 394(3):750-4.

10.Ma, J., Meng, Y., Kwiatkowski, D.J., Chen, X., Peng, H., Sun, Q., Zha, X., Wang, F., Wang, Y., Jing, Y., Zhang, S., Chen, R., Wang, L., Wu, E., Cai, G., Malinowska-Kolodziej, I., Liao, Q., Liu, Y., Zhao, Y., Sun, Q., Xu, K., Dai, J., Han, J., Wu, L., Zhao, R.C., Shen, H. and Zhang, H. (2010) Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest. 120(1):103-14.

11.Chen, L., He, Z., Chen, B., Yang, M., Zhao, Y., Sun, W., Xiao, Z., Zhang, J. and Dai, J.* (2010) Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. J Mater Sci Mater Med. 21(1):309-17.

12.Gao, Y., Wang, B., Xiao, Z., Chen, B., Han, J., Wang, X., Zhang, J., Gao, S., Zhao, Y. and Dai, J.* (2010) Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Stem Cells Dev. 19(1):53-60.

13.Sun, W., Lin, H., Chen, B., Zhao, W., Zhao, Y., Xiao, Z. and Dai, J.* (2010) Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing. J Biomed Mater Res A. 92(3):887-95.

14.Zhao, Y., Zhang, J., Wang, X., Chen, B., Xiao, Z., Shi, C., Wei, Z., Hou, X., Wang, Q. and Dai, J.* (2010) The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. J Controlled Release. 141(1):30-7.

15. Chen, L., He, Z., Chen, B., Zhao, Y., Sun, W., Xiao, Z., Zhang, J., Yang, M., Gao, Z. and (2009) Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. Biomacromolecules. 10(12):3193-8.

16. Sun, W., Sun, C., Zhao, H., Lin, H., Han, Q., Wang, J., Ma, H., Chen, B., Xiao, Z. and Dai, J.* (2009) Improvement of sciatic nerve regeneration using laminin-binding human NGF-beta.PLoS One. 4(7):e6180.

17.Yang, Y., Zhao, Y., Chen, B., Han, Q., Sun, W., Xiao, Z. and Dai, J.* (2009) Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. Tissue Eng Part A. 15(11):3589-96.

18. Wang, B., Gao, Y., Xiao, Z., Chen, B., Han, J., Zhang, J., Wang, X. and Dai, J.* (2009) Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells. Neurosci Lett. 461(3):252-7.

19.Sun, W., Sun, C., Lin, H., Zhao, H., Wang, J., Ma, H., Chen, B., Xiao, Z. and Dai, J.* (2009) The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials. 30(27):4649-56.

20. Ding, W., Lin, L., Ren, F., Zou, H., Duan, Z. and Dai, J.* (2009) Effects of splice sites on the intron retention in histamine H3 receptors from rats and mice. J Genet Genomics. 36(8):475-82.

21. Ding, W., Lin, L., Xiao, Z., Zou, H., Duan, Z. and Dai, J.* (2009) Multiple sequence elements determine the intron retention in histamine H3 receptors in rats and mice. Int J Biochem Cell Biol. 41(11):2281-6.

22. Gao, Y., Xiao, Z., Chen, B., Wang, B., Han, J., Zhao, Y., Zhang, J. and Dai, J.* (2009) Effect of different regions of Nogo-A on the differentiation of neural progenitors. Neurosci Lett. 458(3):132-5.

23. Han, Q., Sun, W., Lin, H., Zhao, W., Gao, Y., Zhao, Y., Chen, B., Xiao, Z., Hu, W., Li, Y., Yang, B. and Dai, J.* (2009) Linear ordered collagen scaffolds loaded with collagen-binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats. Tissue Eng Part A. 15(10):2927-35.

24. Wang, X., Zhao, Y., Xiao, Z., Chen, B., Wei, Z., Wang, B., Zhang, J., Han, J., Gao, Y., Li, L., Zhao, H., Zhao, W., Lin, H. and Dai, J.* (2009) Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. Stem Cells. 27(6):1265-75.

25. Zhang, J., Ding, L., Zhao, Y., Sun, W., Chen, B., Lin, H., Wang, X., Zhang, L., Xu, B. and Dai, J.* (2009) Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 119(13):1776-84.

26. Sun, B., Chen, B., Zhao, Y., Sun, W., Chen, K., Zhang, J., Wei, Z., Xiao, Z. and Dai, J.* (2009) Crosslinking heparin to collagen scaffolds for the delivery of human platelet-derived growth factor. J Biomed Mater Res B Appl Biomater. 91(1):366-72.

27. Zhao, W., Han, Q., Lin, H., Sun, W., Gao, Y., Zhao, Y., Wang, B., Wang, X., Chen, B., Xiao, Z. and Dai, J.* (2009) Human basic fibroblast growth factor fused with kringle4 Peptide binds to a fibrin scaffold and enhances angiogenesis. Tissue Eng Part A. 15(5):991-8.

28. Zhao, Y., Lin, H., Zhang, J., Chen, B., Sun, W., Wang, X., Zhao, W., Xiao, Z. and Dai, J.* (2009) Crosslinked three-dimensional demineralized bone matrix for the adipose-derived stromal cell proliferation and differentiation. Tissue Eng Part A. 15(1):13-21.

29. Zhao, Y., Chen, B., Lin, H., Sun, W., Zhao, W., Zhang, J. and Dai, J.* (2009) The bone-derived collagen containing mineralized matrix for the loading of collagen